How Long Does Vyvanse Stay in Your System

The scientific name for Vyvanse is Lisdexamfetamine. Often prescribed to people with attention deficit hyperactivity disorder, it is used as a total treatment plan. This medication takes the place of social, psychological and other treatments.

How Vyvanse is used

Vyvanse can be taken with or without food. Most doctors recommend taking it one time a day in the morning. If taken later in the day, patients may experience problems sleeping. The capsule may be opened and the contents dissolved in a glass of water for those who have problems swallowing. The mixture must be taken immediately. Do not allow it to set.

What to tell the doctor

Before taking Vyvanse, discuss the advantages and disadvantages of using this medication. Let the doctor know of any heart- or mental-related problems that you have or may have experienced. Be sure to inform the doctor if you are pregnant, nursing a baby or planning to become pregnant while taking Vyvanse. The doctor will need to know all of the prescription and non-prescription medicines you are currently taking.

How long Vyvanse stays in the system

Vyvanse has some effect medically on the person taking it for up to 14 hours. However, it can stay in the person's system from 48 hours up to a maximum of two weeks. This may present a problem for those who have to do regular drug testing, because Vyvanse can show up as amphetamine in both the urine and the hair test. The best thing to do is take the prescription from your doctor with you when you go for testing.

Side effects and symptoms

The majority of the people taking Vyvanse do not experience any side effects (.pdf) or adverse symptoms. However, some side effects may occur, including:

  • Swelling of ankles and/or feet
  • Outbursts of sounds or words
  • Extreme tiredness
  • Rapid weight loss
  • Change in sexual interest or ability
  • Muscle twitching
  • Uncontrolled movements
  • Aggression
  • Depression
  • Abnormal behavior or thoughts
  • Mental, mood or behavior changes

If a patient experiences any of these symptoms and notices that they do not stop or they get worse, the doctor should be told right away. Other side effects to watch for include: sweating, irritability, headaches, nervousness, dry mouth, dizziness, weight loss, restlessness, nausea, vomiting, loss of appetite, stomach or abdominal pain or dry mouth.

Call 911 or take the patient to the emergency room if they experience shortness of breath, pain in the left arm, jaw or chest, fainting, slurred speech, sudden vision changes, confusion, weakness on either side of the body or seizures.

Activities to avoid

Because this drug may cause dizziness, do not drive or use machinery while taking it. Be extremely careful not to drink much alcohol. Do not participate in any type of activity that requires alertness.


Vyvanse should only be used during pregnancy if it is absolutely necessary. If the mother is dependent on this medication, it is not uncommon for the baby to be born too early and have a low birth weight. The baby may also suffer withdrawal symptoms. Breast feeding is not recommended because the medication passes into the breast milk. Vyvanse can have adverse effects in a newborn.

How to store Vyvanse

Like all medications, Vyvanse should be stored out of reach of children. Store this medication in a place with a moderate temperature. Keep it out of direct light.

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